TURN THAT FROWN UPSIDE DOWN by Wren Schultz courtesy of www.blogduwren.com
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 DOWN
1. Shriner's cap
2. Audit org.
3. World capital built from scratch in 1956
4. Inflammatory or depressant prefix
5. Mnemonic trick for remembering quadratic expansion in algebra
6. Sub-woofer's counterpart
7. Flu, e.g.
8. "D-Nevada" follows his name on CSPAN
9. Didn't give away
10. Way
11. Bear in Boliva
12. Gin inventor Whitney
19. James of Elf
22. AKA Angel Dust
23. Semi-precious stone
26. Straighten (up)
27. B&O, e.g.
29. Like a theme sometimes
30. British arm
32. Civil rights org.
33. "People who wear glasses are smart", e.g.
35. Brings to a close
37. MBA course
41. Continental abbr.
42. Palindromic simile center
43. Vehicle capable of high occupancy
44. Sounds heard near a nursery
45. Mountain located in the Siskiyous
46. Ken or G.I. Joe
49. Stella _____
50. Swampy river
51. Ancient Tokyo
53. Unagi
55. Baby's wail
57. Subject to high heat
58 Trans-am feature, maybe
60. Dallas to Houston dir.
61. Ground zero, abbr.
62. Science Friday host Flatow
ACROSS
1. White lie
4. Not fore
7. Upset
10. Jane or John
13. Be human
14. PBS news show
15. See 66-Across
16. Emigrant's course
17. When doubled, Eva's sister
18. Male dress-up accessory
20. Miss Piggy's pronoun
21. With 52, 55, and 59-Across, saying represented by this puzzle
22. Luau treat
24. ___-Bo, workout craze
25. Busy mo. for 2-Down
28. Barely above average
31. USNA grad.
32. Actor Ed
34. Dinghy tether line
36. Areas
 38. Piled high
39. Research assistant, as in law
40. Challenger replacement
44. Out of this world prefix
47. Women's suffrage Anthony
48. Go slow
52. See 21-Across
54. Campaigned
55. See 21-Across
56. "You know you want to"
58. Permanent reminder of a temporary feeling
59. See 21-Across
63. "Hut" preceder, sometimes
64. Nolan Ryan, once
65. Babe, for one
66. With 15-Across, Brokeback Mountain director
67. Post-game show feature
68. the ISO 3166-1 alpha-3 code for Western Sahara (I'm sorry about this one)

Solution can be found at http://www.blogduwren.com/crosswords/crossword28_solution.gif.
Printable version can be found here.