PREFIX PLAY by Wren Schultz courtesy of Blog du Wren (http://www.blogduwren.com).
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DOWN
1. Eat out add on
2. Tweaked, as for the screen
3. "Show me!"
4. Poet Silverstein
5. Basra denizen
6. Last name of comedic brothers
7. Gravity or Christ lead-in
8. Harvest
9. Iron alloy
10. What many children are afraid of
11. Actor Brynner
12. Most common pluralizer
14. North of Iran-Contra scandal
21. Be human
22. Cut's partner
23. "__ tree falls in the woods..."
26. West of Hollywood
27. Not rent
29. University figure
31. Hawaii or Tahiti, poetically
32. Tire gauge readout
35. It's a terrible thing to waste
36. "Work without ____"
38. The _______ Suspects, 1995
39. ___ Spiegel, German magazine
41. It's often over nothing
42. 40 winks
43. How you may be running after a long day
44. Weeds setting
46. They might be against you
47. Mama goats
48. Ampersand, verbally
51. Computer hardware company
52. Tenochtitlan resident of old
54. It's often asked for but rarely received
56. Winning margin is a close race
59. Michelle Wie's org.
60. "You have nothing to ____"
61. Head light?
62. Witchy woman
63. Mouths, to a biologist
66. Superlative suffix
ACROSS
1. Tic ____
5. Construction spanner
9. Eye issue
13. The Gem State
15. Magritte or Descartes
16. Ergo
17. Auto body section
18. Utah ski resort
19. Sniggles
20. Having all ones medications?
23. ___ Wonderful Life
24. Colored part of the eye
25. Well-remembered mission
28. Pine cone/peanut butter creation
30. Femur termini
33. Crudites, by definition
34. Chick follower
35. She's got a boyfriend?
37. A4 maker
40. Mortgage term
41. Delayed logic?
45. Sicilian spewer
49. 2007 Steve Carell title role
50. Asian tongue
51. Handwerker of hot dog fame
53. Bizet forte
55. Female counterpart to Dylan at Woodstock
57. Cease
58. To sell stuff, e.g.?
62. Arizona native
64. Pablo's pooch
65. Pearl Jam's Vedder
67. B.A. part
68. Goes on and on
69. Hands over peaceably
70. Motown maven Marvin
71. Irish backside
72. He may be personal, abbr.

Solution can be found at http://www.blogduwren.com/crosswords/crossword25_solution.gif.
Printable version can be found here.